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Annals of Internal Medicine , 138(1), 19

Pacing your dose escalation according to tolerancesometimes staying at one level for an extra weekallows your system to adjust without derailing treatment

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Seek urgent medical advice (contact 111 or your GP) if you experience: Severe or persistent abdominal pain , particularly if accompanied by vomiting this could indicate pancreatitis, a rare but serious side effect that requires immediate assessment Signs of gallbladder problems pain in the upper right abdomen, fever, yellowing of skin or eyes Symptoms of thyroid problems lump or swelling in the neck, persistent hoarseness, difficulty swallowing Severe dehydration inability to keep fluids down, dizziness, reduced urination, confusion Hypoglycaemia symptoms in patients with diabetes particularly if taking insulin or sulfonylureas alongside Wegovy Contact your GP or diabetes team for non-urgent concerns such as: Significant weight regain (more than 5% of body weight) within weeks of stopping Difficulty managing appetite or eating behaviours Changes in blood glucose control requiring medication adjustment Persistent gastrointestinal symptoms beyond 4 weeks after the last dose Questions about restarting Wegovy or alternative weight management options If you stopped Wegovy due to side effects , inform your prescriber so they can document this in your medical records and consider reporting via the Yellow Card Scheme

Immunogenic cell death in cancer and infectious disease