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Ruggenenti, P., Cattaneo, D., Loriga, G., Ledda, F., Motterlini, N., Gherardi, G., Orisio, S., and Remuzzi, G

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In practice, clinics adapt trial titration schedules by starting most patients at 1 mg once weekly for 24 weeks, which is considered the safest entry point for minimizing GI side effects