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Phosphorylation of AKT was increased in GNE knockdown cells after IGF-1 treatment while ERK phosphorylation was reduced

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All interventions were compared with current use of SGLT2is (20% of the total population) and GLP-1 RAs (5% of the total population)

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MC4R integrates anorectic signals derived from alpha-melanocyte-stimulating hormone (MSH) and orexigenic signals generated by agouti-related peptide (AGRP) [3, 4]

goal: antifungal with safe hepatic metabolism