Performed as part of the FOUNTAIN (FinerenOne mUlti-database NeTwork for evidence generAtIoN) platform [16], the aims of this study were to describe treatment changes over time in patients with type 2 diabetes and CKD initiating treatment with either an SGLT2i or a GLP-1 RA and to describe changes in the baseline characteristics in these cohorts with the evolution of the treatment landscape, specifically before and after FDA approval of finerenone in 2021
The time-resolved data obtained by single-cell confocal microscopy of green fluorescent protein (GFP) reporters and qPCR of the Nrf2 pathway components complemented with siRNA knock down experiments, is accurately described by the calibrated mathematical model
Treatment of patients with small-molecule antioxidants or antioxidant enzymes did not yield the desired benefits (Lirussi et al
Antioxidant capacity changes are happening at the biochemical level from the first dose, but the felt experience varies based on baseline oxidative stress, sleep, and overall health
Improving insulin sensitivity : This can contribute to more stable blood sugar levels, which is beneficial for both weight management and overall metabolic health
It supports angiogenesis, tissue repair, and the modulation of transforming growth factor beta 1 (TGF1) signaling