One possible explanation comes from studies on the effect of AChEIs in other neurodegenerative conditions
Even though there have been no studies evaluating this approach, its something we definitely see in clinical practice. Who should consider microdosing GLP-1s
Psychopharmacology 233 , 26552661 (2016)
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[8] [18] Whilst nausea is a common class effect of GLP-1 receptor agonists, it's important to distinguish normal, expected nausea from symptoms that require medical attention
Semaglutide primarily works by activating the GLP-1 receptor, which helps regulate appetite, satiety, food noise, gastric emptying, and blood sugar-related signaling