It plays a critical role in neutralizing free radicals, recycling other antioxidants like vitamins C and E, and maintaining the bodys detoxification pathways
This contrasts sharply with orthobiologic therapies like PRP and mesenchymal stem cell therapies, both of which have been evaluated in multiple randomized controlled trials and large observational studies
Yu Y, Jin L, Zhuang Y, Hu Y, Cang J, Guo K
doi: 10.1111/ALL.15977 209 WilkinsonMHartAMilanSJSugumarK
GPx4 is also considered a tumor suppressor because it is down-regulated in tumors [23, 43]
MDSCs as pillars of immunosuppressive network MDSCs are critical components of the tumor microenvironment and play a pivotal role in the failure of various immunotherapeutic approaches, including ICIs, CAR-T, CAR-NK, CAR-NKT, CAR-macrophage (CAR-M), oncolytic virus, and cancer vaccine [10]