It is generally well-tolerated, with the following side effects [9][18]: GI symptoms (most common): Nausea, vomiting, diarrhea, and abdominal discomfort, particularly at doses above 1,200 mg/day Sulfurous taste/smell: NAC has a distinct sulfur odor and taste that some find unpleasant Headache: Occasionally reported Anaphylactoid reactions (IV use only): Infusion-related reactions including flushing, itching, bronchospasm, and hypotension occur in approximately 10-20% of patients receiving IV NAC for acetaminophen overdose [18] Upper limit: There is no established UL for NAC
Insomnia and poor sleep in CKD: a systematic review and meta-analysis
Also of concern is the possibility of Stevens-Johnson Syndrome
Some people also notice an improvement in their overall sense of well-being and a reduction in symptoms associated with deficiency, such as tingling or numbness in the extremities
Toxic burden
Depletion of GSH can lead to, among other things, mitochondrial dysfunction and cell death