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It is the most clinically studied of the three, with topical trials showing collagen, fine-line, and skin-density changes, and a large body of in-vitro work on gene expression and wound healing
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Its inhibition has emerged as a promising strategy to enhance antitumor immunity, including in aggressive cancers such as glioblastoma
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However, the contributions of specific LOX isoforms to total LOX activity in situ can be determined by the inclusion of isoform-specific inhibitors or knockout studies
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