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Of note, the IGF-IR downstream effectors Akt and mTOR promote the repair of radiation-induced DNA double strand breaks and confer resistance to radiotherapy [93, 94]

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1 Introduction Migraine manifests as a chronic neurovascular disease characterized by unilateral or bilateral throbbing severe headaches, predominantly unilateral, recurring with symptoms such as nausea, vomiting, photophobia, and phonophobia that impair autonomic nervous system functions (Steiner and Stovner, 2023) many sufferers cannot perform normal or work activities

They suggest a potential new way to target the disease

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