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While both clinical and real-world results have shown these medications can improve heart health, new research has found a downside: People who stop taking them quickly lose these improvements and may be at an increased risk of heart attack, stroke, and even death compared with people who stay on them consistently

FDA: The latest Alliance for Pharmacy Compounding, accessed December 19, 2025, Compounded GLP-1 Drugs: Texas Judge Denies PI Motion and Request for Stay of FDAs Declaration that Tirzepatide Shortage is Resolved

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Weight loss continued as calorie intake remained lower Participants taking semaglutide achieved significant weight loss over the course of the study, with an average loss of 15.1 percent of initial body weight after 60 weeks of treatment