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Because semaglutide is a biologic, future versions may be regulated as biosimilars, not traditional generics, requiring additional clinical data and a longer approval process
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Notably, the hyperglycemic and high-AGE microenvironment within the DW vasculature and surrounding tissue actively reinforces and sustains the pro-inflammatory M1 macrophage phenotype through multiple interconnected mechanisms (Fu et al., 2023)
Within this context, the parent antibody, zanidatamab (the Bispecific antibody component of ZW49), demonstrated compelling clinical activity both as a monotherapy and in combinations, presenting a broader and more immediate developmental path [61]
Risk factors include the speed and magnitude of weight loss, pre-existing nutritional deficiencies, age, sex (women are more commonly affected), and individual genetic susceptibility