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This dissociation between anti-inflammatory efficacy and bone-preserving capacity suggests that suppression of systemic inflammation may not be sufficient to reverse or prevent skeletal damage, especially in models with advanced joint destruction

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the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science

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