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In ATTAIN-1, 3,127 overweight participants without diabetes were enrolled, while in ATTAIN-2, 1,613 overweight patients with type 2 diabetes were enrolled
doi: 10.1002/cpt.1548, 93 NashY.SchmuklerE.TrudlerD.Pinkas-KramarskiR.FrenkelD
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While there is mechanistic support for this (different receptor occupancy thresholds), it has not been definitively demonstrated in human studies
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