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The peptide, derived from the C-terminal fragment of human growth hormone (amino acids 176-191), targets adipose tissue specifically without the broader metabolic effects associated with full growth hormone therapy
1-2
Shaoyao-gancao decoction ameliorates the inflammation state in polycystic ovary syndrome rats via remodeling gut microbiota and suppressing the TLR4/NF-B pathway
doi: 10.1038/srep27524 49
Interestingly, both in vitro and in vivo studies report that V-type and the adjacent C1-type domains are able to form structural and functional VC1 tandem unit with multiple binding sites to recognize numerous different RAGE ligands (8789)
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