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In animal models, C2 supplementation promoted neuroplasticity, synthesis of neurotrophic factors, modulation of glutamatergic dysfunction, reversal of neuronal atrophy in regions like the hippocampus and amygdala, and improvement in depression-like behavioral symptoms [20, 30, 57, 58]

Tirzepatide with niacinamide is another combination that researchers use for complementary support

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When GLP-1 binds to receptors in the brain and gut, it triggers a cascade of effects: the stomach empties more slowly, hunger signals diminish, and insulin release becomes more efficient