Get professional input if you have a history of eating disorders
While the efficacy data for retatrutide is exceptionally promising, maintaining rigorous clinical oversight is paramount
I have found that patients who lose weight slowly do better in the long termit seems to give skin the ability to adapt to changes and shrink down to the new underlying shape. The nutritional point, in particular, may play an outsize role, says Rajesh Dhirmalani, DO, a gastroenterologist in New Jersey, and medical advisor to Replenza, a nutritional support brand for GLP-1 users

According to FDA prescribing information, these effects vary by product and dose: For Ozempic (diabetes treatment): Nausea (15-20% of patients) Diarrhea (8-9% of patients) Vomiting (5-9% of patients) Constipation (3-7% of patients) Abdominal pain (5-6% of patients) For Wegovy (weight management), gastrointestinal effects are more common at the higher therapeutic dose: Nausea (up to 44% of patients) Diarrhea (up to 30% of patients) Vomiting (up to 24% of patients) Constipation (up to 24% of patients) Abdominal pain (up to 20% of patients) These effects are generally mild to moderate and tend to diminish with continued use
Biomedicines , 10 (11), 2696
Activation of adenosine A2A and dopamine D1 receptors stimulates cyclic AMP-dependent phosphorylation of DARPP-32 in distinct populations of striatal projection neurons