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The metabolic dysfunction is followed by adipokines, inflammatory mediators like TNF-, IL-6, and oxidative stress, which worsen NAFLD and lead to T2DM
The long-term effects of semaglutide use for weight loss are still being studied
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This work represents one of the first demonstrations of FOXO4-DRI activity in primary human cells, supporting translational relevance beyond the initial mouse model findings
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Gross JA, et al
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