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reported an observational comparative study that compared nerve excitability in patients with type 2 DM who received exenatide (n=32), a dipeptidyl peptidase-4 (DPP-4) inhibitor (n=31), or a sodium-glucose cotransporter-2 (SGLT-2) inhibitor (n=27) ( In a retrospective cohort study, Lin et al
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Notably, liraglutide treatment significantly inhibited activated sodium-glucose co- transporter-2 (SGLT2) restored depressed insulin receptor substrate 1 (IRS1), and increased protein kinase G (PKG) levels
#ObesityMedicine #Endocrine #Research #NEJM To view or add a comment, sign in Eloralintide, a selective amylin receptor agonist for the treatment of obesity: a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial To view or add a comment, sign in 2,867 followers
Variants in FTO (the fat-mass and obesity-associated gene), GLP1R (the receptor every GLP-1 compound binds), MC4R (a melanocortin receptor central to satiety), and TCF7L2 (tied to glucose handling and GLP-1 secretion) describe the metabolic terrain a clinician prescribes into
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