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NCT04255433) is expected to provide definitive answers on the impact of tirzepatide on cardiovascular disease compared with dulaglutide, a long-acting GLP-1 RA that has been shown to be cardioprotective in individuals with type 2 diabetes at increased cardiovascular risk [31]

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yet these agents may favor an increase of lean mass and mimic an energy deprivation state with increased ketogenesis (i.e., BHB) through increased circulating GH levels ( Figure 1 )

Additionally, ensure you stay adequately hydrated, as dehydration can sometimes influence heart rate, and actively manage stress through relaxation techniques, given its potential impact on heart rate and palpitations