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GH secretion was increased after CJC-1295 administration with preserved pulsatility confirming that continuous GHRH-receptor stimulation enhances both trough and mean GH secretion while maintaining the pulsatile architecture essential for physiological GH axis function

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In contrast, long-acting agents appear to have a larger effect on lowering fasting glucose due to their effect to increase insulin release and inhibit glucagon release (Meier 2012)

Zheng A, Li H, Cao K, Xu J, Zou X, Li Y, et al