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Several studies, such as this one, have reported significant pain with water-based injections, and little to no pain with those prepared in saline

With MicroRejuve, were injecting Botox in very small quantities throughout the face to improve fine lines, contract pores and decrease redness

In addition, a deficiency of vitamin B12 can cause facial signs such as hyperpigmentation (dark spots), vitiligo (white patches where skin loses color), or angular stomatitis (inflammation at the corners of the mouth)

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