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That number comes from a meta-analysis of 21 semaglutide clinical trials involving over 26,000 participants, and it has understandably alarmed anyone currently injecting this GLP-1 receptor agonist for weight loss or blood sugar management

Many patients notice changes within the first few weeks, though results build over months

Clinical trials particularly the PIONEER 3 and PIONEER 7 studies confirm that oral semaglutide is significantly more effective than sitagliptin for glycemic control and weight loss in patients with type 2 diabetes

Clinics should establish follow-up protocols that support safe prescribing and ongoing patient monitoring

Bmj 337 , a1344 (2008)

It is approved for chorea associated with Huntingtons disease, which is one of the symptoms of the condition that is characterized by involuntary, jerky movements