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Mendelian randomization analysis suggests a potential genetic link between increased opioid use and the risk of major depressive disorder (MDD) and anxiety-related disorders 62

Carrageenan-induced inflammation promotes ROS generation and neutrophil extracellular trap formation in a mouse model of peritonitis

References [1] National Library of Medicine, Enhancing the Oral Bioavailability of Glutathione Using Innovative Analogue Approaches, Yin, N., Harris, P.W.R., Liu, M., Sun, J., Chen, G., Wen, J., Brimble, M.A., March 2025

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Defective autophagic degradation promotes accumulation of intracellular autoantigens and enhances presentation of self-derived peptides, contributing to loss of self-tolerance

The study confirmed FOXO4-DRI was effective across senescent cells generated by different methods (irradiation, doxorubicin, and replication stress), and documented that pre-treatment with FOXO4-DRI attenuated the dedifferentiation of chondrocytes during in vitro expansion establishing it as a valuable tool for research into senescent cell biology in cartilage and musculoskeletal models