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Orlistat is the most modest of the approved options in terms of weight loss

This dual action creates a physiological pulsatile pattern similar to youthful GH secretion profiles

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At 6 wk of age, mice underwent a battery of behavioural tests (described in detail below) while treatment continued

This work demonstrated that GLP-1RA treatment was associated with a significant 29% reduction in MALOs compared to non-use (IRR: 0.71, 95%CI: 0.57-0.88, P = 0.003) over a median follow-up of approximately 70,045 patient-years

Szkudelski and Szkudelska, 2015)