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In hyperglycaemia, diacylglycerol is synthesized de novo from dihydroxyacetone phosphate, which is an intermediate product of glycolysis that then activates PKC [39]
Serious but rare adverse events with tirzepatide include pancreatitis, gallbladder disease, and contraindication in patients with personal or family history of medullary thyroid carcinoma
Baranska A, Blaszczuk A, Kanadys W, et al
Extra caution is appropriate in patients with active cancer, recent cancer, unexplained masses, unexplained weight loss, pregnancy, breastfeeding, known allergy to peptide products, active infection, immune compromise, significant liver or kidney disease, active inflammatory or autoimmune disease flares, unusual clotting history, uncontrolled cardiovascular disease, use of chemotherapy or immune-modifying biologic therapy, and competitive athletes subject to anti-doping rules
However, breastfeeding and pregnant women need about 2.8 mcg and 2.6 mcg, respectively