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Afamelanotide primarily targets MC1R, while melanotan-2 activates MC1R, MC3R, MC4R, and MC5R
A phase 2 clinical trial published in JAMA (2023) reported significant reductions in body weight and improvements in metabolic markers
doi: 10.18632/aging.102944 31 CallaghanBCGaoLLiYZhouXReynoldsEBanerjeeMet al
One of the key findings of our work is that C32E8.9 abolishes mitochondrial translation inhibition extended lifespan without altering UPR mt activation
The simple answer is no
PMID 41109071
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