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The theory is that long-term use of semaglutide, particularly without a controlled diet, could lead to vitamin B12 deficiency due to the effects on gastric emptying

For a broader overview of healing peptide research, see the Peptides for Joint and Tendon Repair guide

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B12 injections are not meant to replace a healthy lifestyle

doi:10.4103/1673-5374.320969 Huang T, Zhang K, Sun L, Xue X, Zhang C, Shu Z, Mu N, Gu J, Zhang W, Wang Y, Zhang Y, Zhang W