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If the provider determines that semaglutide is a better fit than tirzepatide based on your medical profile, they will recommend accordingly

The scientific limitations of transdermal delivery for large molecules make their marketing claims implausible, and no clinical evidence supports their effectiveness for weight loss

That could still be 28 to 60 days depending on the formulation

However, as animal models and isolated tissue experiments were mainly used, the authors cautioned that further research is needed to establish whether the same mechanism occurs in humans