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First-generation GLP-1 receptor agonists necessitated once or twice-daily dosing, resulting in substantial peak-to-trough variations that caused inconsistent glycaemic regulation and heightened gastrointestinal adverse effects (Nauck and Meier 2019)

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Common Side Effects Facial flushing or warmth Nausea, stomach discomfort Chest tightness or pressure (usually dose/rate dependent) Headache Fatigue after administration Injection site discomfort, redness, or swelling Mild dizziness Seek Medical Attention For Severe chest pain or difficulty breathing Signs of allergic reaction: hives, facial swelling, throat tightness Fainting or severe dizziness Use in Pregnancy and Breastfeeding The safety of NAD+ therapy during pregnancy and breastfeeding has not been established

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