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Phen-Fen (phentermine + fenfluramine) was the GLP-1 of its day effective for weight loss, but discontinued in 1997 for causing heart-valve damage and pulmonary hypertension

1.Vachiramon V, McMichael AJ

Further profiling indicated that the altered intestinal TJ proteins and T cell homeostasis seen in hyperinulin-treated mice might be related to the high production of SCFAs by bacteria of the family Ruminococcaceae and Bifidobacterium spp (60)

The EMPA-KIDNEY trial enrolled a larger proportion of participants without diabetes mellitus and included individuals with lower mean eGFR (37.3 mL/min/1.73 m) and median UACR (329 mg/g) compared to DAPA-CKD

Metabolic Acidosis and Kidney Stones Topiramate increases the amount of bicarbonate your kidneys excrete

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