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1 Furthermore, reduced glutathione (GSH) acts as a hydrogen donor in the detoxification of hydrogen peroxide

Drugs targeting mitochondrial dynamics, autophagy, mtDNA repair, calcium homeostasis, and oxygen adaptation strategies play a key role in maintaining oxygen balance and offer promising therapeutic approaches for a variety of diseases

doi:10.1146/annurev.biochem.72.121801.161828

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Research has used MT-1 to characterise these melanin-independent photoprotection mechanisms and establishing that MC1R activation provides a layer of cellular UV protection through DNA repair enhancement and oxidative stress reduction thats distinct from and additive to the physical UV-screening function of melanin pigmentation