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FIGURE 3 The immunopharmacological effects of GSH are evident through several distinct but interconnected pathways, including regulation of inflammatory signaling networks like MAPK and NF-B, buffering of pathologic ROS as well as maintenance of cellular ROS signaling, and modulation of both peripheral and central immune cell activity (Ghezzi, 2011

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There are also alternative proline catabolic pathways that cleave proline into two-carbon molecules, yet are NAD + dependent, so these metabolic pathways are suppressed in the gdh3 / gdh3 mutant

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