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In summary, both direct design relying on mechanistic knowledge and available structural data from the oxytocinase subfamily of M1 aminopeptidases as well as iterative manipulations of the parent peptide Ang IV, involving insertion of unnatural amino acids as -amino acids, macrocyclizations and various structural simplifications have provided highly potent selective Ang IV peptidemimetics inhibiting IRAP

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Mild cognitive impairment (MCI) is a condition characterized by noticeable cognitive decline more significant than expected for an individual's age but does not interfere significantly with daily functioning

WB Saunders, pp 117134

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