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In primary hypogonadism, the brain functions normally and sends a signal to the testes to produce testosterone

doi: 10.1016/j.cmet.2013.06.018 62 PesslerFMayerCTJungSMBehrensEMDaiLMenetskiJPet al

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Higher concentrations may offer some stability advantages in certain formulations because the peptide-to-surface ratio is more favorable, but they can also increase the risk of aggregation if the formulation is not optimized for that concentration

Initial optimization (months 1-3)

Specifically, [Ca 2+ ] cyt rapidly increased to the peak value in leaf 6 at ~230 s upon treatment on leaf 1 with GSH rather than sorbitol (Fig