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J Med Screen 4: 181, 1997 245 Wald NJ, Watt HC, Hackshaw AK: Integrated screening for Down's syndrome based on tests performed during the first and second trimesters
Single site mutations at asparagine residues were shown to result in a functionally active yet slightly less thermally stable version of the enzyme in vitro, while knockout of all asparagine residues resulted in an accumulation of the uncleaved, propeptide form of the enzyme
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