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International variations in regulatory status can create confusion and may limit access to these therapies in certain jurisdictions

TNF- knockout mice were protected against these effects

Governments will increasingly demand favorable cost-benefit evidence, may cap prices, may restrict access, or enforce demonstration of long-term safety more rigorously

For clinicians caring for women with T2DM today: Individualize therapy: recognize that women may derive equal or greater weight benefits from GLP-1 therapy but may also face more GI adverse eventscounseling and slow up-titration can improve persistence

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Problemi neurologici: in rari casi, pu esacerbare sintomi di disturbi convulsivi o bipolari