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9,10 Summary A large body of high-quality evidence suggests that in patients with obesity without diabetes, GLP-1 and GIP/GLP-1 receptor agonists are associated with significant regain of lost weight after therapy discontinuation

Additionally, injecting into areas with potentially reduced absorption, or failing to rotate injection sites may result in inconsistent drug delivery

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Physiol Behav 196:95103

J.2001Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings.461-3,326

Recent studies have shown mixed results regarding semaglutide and liver damage