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[15] Serious but infrequent events-such as angioedema, bronchospasm, hypotension, or urticaria-reflect IgE-mediated hypersensitivity and may require desensitization or substitution with hydroxocobalamin
Ensuring proper administration technique (IM deep into muscle, or IV slowly diluted) also helps minimize adverse effects like injection pain or vein irritation
Injection Frequency : For patients requiring frequent B12 injections, using a thinner gauge needle (especially for SC injections) can reduce tissue trauma and discomfort over time
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[3] One study focused on the potential role of the tripeptide concerning dermal papilla cells (DPCs)