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A post hoc meta-analysis used a predictive model to evaluate the cardiovascular risk of patients from all PIONEER and SUSTAIN clinical trials (n = 18 studies) [61]

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others are gentler but may lack efficacy for certain research goals

References [1] Wilding, J

Hence, if retatrutide acted by stimulation of adenylyl cyclase, then an inhibition of this cyclase by carbachol and PIA would explain the negative inotropic effect of carbachol and PIA in the presence of retatrutide