Evaluating semaglutide and tirzepatide in early non-responders While semaglutide produces 15-17% mean weight loss and tirzepatide yields even more impressive 16-22.5% reductions, neither has been thoroughly evaluated in early non-responders
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Recently, the newly developed drug tirzepatide, which targets both the GLP-1 and glucose-dependent insulinotropic polypeptide (GIP) receptors, was introduced to the market to treat type 2 diabetes and obesity in 2022 and 2023, respectively (Table 1)
Concerning weight change and BMI reduction, our analysis found no significant difference between Dulaglutide (administered at dosages ranging from 0.75 to 1.5 mg once weekly) and Semaglutide (administered at dosages ranging from 0.5 to 1 mg once weekly)