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Chronic pain lingers for months or years, often because of ongoing inflammation, nerve changes, or tissue that never fully healed
Although not universally observed, studies suggest that individuals taking semaglutide and tirzepatide may experience a significant loss of lean muscle mass, along with fat mass (15-60% of weight loss)
References (1) Thakkar K1, Billa G2
Larger randomised controlled trials in humans have not yet been completed
& Bockenstedt, L
3 In an additional key secondary endpoint, participants taking orforglipron lost an average of 16.0 lbs (7.9%) at the highest dose
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