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Similarly, although hepatic dysfunction can occur with large niacin doses (1-3 grams daily over months) causing elevated liver enzymes or jaundice, niacinamide at 100 mg is very unlikely to have any adverse effect on the liver

LeWine, MD, Chief Medical Editor, Harvard Health Publishing

"Nicotine from cigarette smoking enhances clonidine-induced increase of serum growth hormone concentrations in men"