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377,378,379 IDH1 mutations in human cancers favor consuming the NADPH for 2-HG synthesis at the expense of other NADPH-requiring pathways essential for cell viability even when NADPH is limiting

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In combination with semaglutide (CagriSema 2.4/2.4 mg) Phase 2 demonstrated weight reduction up to 15.6 % over 32 weeks

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