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Paraxanthine, the primary metabolite of caffeine, provides protection against dopaminergic cell death via stimulation of ryanodine receptor channels
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Sixth, stratified analyses resulted in some groups with a relatively low number of participants and events, where risk estimates should be considered as exploratory findings
"They can also increase the risk of nausea, vomiting, diarrhea, constipation, and other GI side effects all of which can be made worse by dehydration." Jessica Crandall Snyder, a registered dietitian and a medical advisor to FuturHealth, noted the issue is even more important in warmer weather