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275 Another smaller phase 2 study enrolled 71 patients with MASH-related cirrhosis testing 2.4 mg semaglutide once weekly did not reveal significant changes in either the resolution of MASH or improvement in fibrosis despite some improvement of noninvasive markers of disease activity

In other words, glucagon agonism acts somewhat like a metabolic accelerator, burning more calories at rest

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The patients experienced a statistically significant improvement from baseline to the end of the observation in pain intensity on VAS (from 75.9 1.56 to 51.9 1.99

If you want the mechanism in plain terms first, start with what peptide therapy is and how a medically supervised growth hormone axis program is structured