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Despite the intriguing possibility of a pill, all available formulations, like the injectable options, have undergone rigorous testing and approval processes, something which oral alternatives have not yet achieved

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In Phase II trials, MariTide demonstrated up to approximately 20% average weight loss at 52 weeks in people living with obesity or overweight, without evidence of a plateau, suggesting even greater results with longer treatment

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Such an approach illustrates the utility of HDX-MS for mapping PPIs and its potential for elucidating the interactions between excipients and proteins, which would have direct applicability to developability considerations and formulation composition design