In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization
doi:10.1155/2012/324832 Simon A, Wegrowski Y, Bontemps Y, Maquart FX
Pooled analysis including these two studies in addition to SELECT and FLOW [31] reported that semaglutide reduced the risk of hospitalization or urgent visits due to heart failure by 41% (HR 0.59, 95% CI 0.410.82) in HFpEF patients compared with placebo [32]
I was expecting a little more from the first months dose, but will hope for more with month 2
As always, if cravings become a concern, consult your healthcare provider to explore personalized solutions
Can I switch to another treatment