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Aging leads to a loss of CYP19, a key enzyme in estrogen synthesis, resulting in the upregulation of pro-apoptotic genes such as p53 and Bax, thereby promoting granulosa cells apoptosis (Toda et al., 2001)
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Studies noted improvements in serotonin and dopamine balance, crucial neurotransmitters involved in mood regulation
This dual action enhances insulin secretion more robustly than GLP-1 agonists alone, further suppresses glucagon release, and additionally slows gastric emptying
1991 Jul;14(7):598-604