Peripheral effects Via the AMY2 and AMY3 receptors Cagrilintide acts peripherally: Slowing of gastric emptying , stronger than with GLP-1 Suppression of postprandial glucagon , helps control postprandial glycemic spikes Modulation of bone remodeling (via AMY3), a neutral effect, but clinically monitored Synergy with GLP-1 (the mechanistic basis of CagriSema) The main innovation is the complementarity with the GLP-1 pathway : GLP-1 suppresses appetite via the arcuate nucleus of the hypothalamus (POMC neurons, AgRP/NPY inhibition) Amylin suppresses appetite via the area postrema (CGRP-like neurons) Two independent centers, two independent mechanisms
4a) or treatment with the pharmacological inhibitor BSO (Fig
Arthritis Res Ther (2017) 19(1):163
And I'm telling you right now, the drugs are only getting rid of the symptoms
Again, patience is your friend
BPC-157 and GHK-Cu in Wound Healing Research on BPC-157 and GHK-Cu in wound healing focuses on their ability to accelerate tissue repair and promote recovery