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Findings from the ATTAIN Phase III clinical trial programme investigating orforglipron as a tool for weight management will be shared later in 2025

It was initially postulated to be a compensatory mechanism to the blood pressure lowering effect of GLP-1 RAs that was possibly mediated by their vasodilatory effect [9, 31] and/or increased urinary sodium excretion [32]

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Symptoms of overdose includes gastrointestinal disturbances such as nausea